Title: Applications of Uncertainty Quantification to Coagulation Biology
Abstract: Blood coagulation is a complex system comprised of numerous biochemical reactions. Due to this complexity, mathematical modeling has been used to increase the overall understanding of the system as a whole, determine previously unknown mechanisms, and to predict system responses. These models, however, may involve uncertainty in both parameter values and kinetic schemes that describe the reactions. This talk will focus on two such ideas. The first examines the interactions between a specific coagulation factor, FXa, and an experimental tool designed to measure its action, a chromogenic substrate. The second explores how global sensitivity analysis is used on a mathematical model to identify a novel mechanism for recovering a normal clotting response in hemophilia A.